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Cholecystitis

Cholecystitis

Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...

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The Role of Indocyanine Green Fluorescence in Complex Laparoscopic Cholecystectomy Navigation

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Laparoscopic cholecystectomy for acute cholecystitis: does timing matter?

Baiju Senadhipan¹, Sreekanth S Kumar², Srikanth Damodaran Pillai¹

¹Holy Cross Hospital, Kottiyam, Kollam, India.

The Indian Journal of Surgery

|January 16, 2014

Summary

Laparoscopic cholecystectomy is a safe and effective treatment for acute cholecystitis, regardless of symptom onset time. This study found no increase in complications or conversion rates when performed at any stage, supporting early or delayed surgical intervention.

Keywords:

Acute cholecystitis Conversion rates Laparoscopic cholecystectomy Timing of surgery

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Laparoscopic Cholecystectomy with Indocyanine Green Fluorescence: Choledochoscopic Stone Extraction and Primary Duct Suture

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Published on: November 25, 2025

Area of Science:

Gastroenterology
Surgical Oncology

Background:

Acute cholecystitis is a frequent cause of acute abdominal pain.
Laparoscopic cholecystectomy is the standard treatment for acute cholecystitis.
The optimal timing for surgical intervention in acute cholecystitis is debated.

Purpose of the Study:

To evaluate the safety and efficacy of laparoscopic cholecystectomy for acute cholecystitis at different time intervals post-symptom onset.

Main Methods:

A retrospective analysis of 200 laparoscopic cholecystectomies for acute cholecystitis.
Patients were divided into three groups based on time since symptom onset: within 48 hours, 48 hours to 6 weeks, and after 6 weeks.
Surgical duration, conversion rates, intraoperative injuries, and postoperative stay were assessed using statistical tests (Kruskal-Wallis, Mann-Whitney, paired t-tests).

Main Results:

Surgical duration was shortest in the group operated on after 6 weeks (34.2 min) compared to earlier groups (53.5 min and 57.5 min).
No significant differences were observed in conversion rates or major biliary/organ injuries across the three groups.
Postoperative hospital stay was comparable among all groups, averaging around 3 days.

Conclusions:

Laparoscopic cholecystectomy can be safely performed at any time following the onset of acute cholecystitis.
The timing of surgery does not appear to significantly impact complication rates or patient recovery.
These findings support the flexibility in surgical scheduling for acute cholecystitis management.