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Familial occurrence of nonsyndromic wilms tumor-a report in two siblings
Zeenath Begum1, Shameem Sharieff2, Abdul H Attar3
1Department of Pathology, Khaja Bandanawaz Institute of Medical Sciences, H. No. 5-408/5, Khaja Colony, Roza B, Gulbarga, 585104 India ; Department of Pathology, Gulbarga, India.
Abstract:
Nephroblastoma, (otherwise known as nephroblastoma) a second most common malignant neoplasm in childhood has been reported in twins, siblings & successive generations. We report two cases of Wilms tumor in female and male siblings first noticed in each at 14 months of age. No congenital anomalies were observed in these patients. Both patients were treated with surgery & histopathology of both the specimens showed a well differentiated Wilms tumor with favourable histology. On follow up both the patients are alive and in complete remission, 4 years after the diagnosis in female & 6 months after the diagnosis in the male sibling.
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