Molecular biology of lung cancer-a review

Area of Science:

• Oncology
• Molecular Biology
• Genetics

Background:

• Lung cancer is a leading and increasing cancer in Indian males.
• Diagnosis often occurs at late stages, leading to poor survival rates.
• Current research emphasizes molecular profiling for targeted therapies.

Purpose of the Study:

• To review important molecular profiles of lung cancer.
• To highlight receptor tyrosine kinases as key molecular markers and therapeutic targets.
• To discuss molecular alterations driving lung cancer with therapeutic implications.

Main Methods:

• Literature review of current oncology research.
• Focus on molecular profiling and receptor tyrosine kinases.
• Analysis of gene mutations and amplifications in lung cancer.

Main Results:

• Receptor tyrosine kinases (RTKs) are significant molecular targets in lung cancer.
• Mutations and amplifications in RTKs are common.
• Therapeutic options are available for targets like EGFR, ALK, MET, and KRAS.

Conclusions:

• Molecular profiling is crucial for understanding and treating lung cancer.
• Targeted therapies based on molecular alterations offer improved treatment strategies.
• Further research into molecular profiles can enhance patient survival in lung cancer.