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Updated: May 4, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Methyl 2-[(tert-but-oxy-carbon-yl)amino]-3-(4-hy-droxy-phen-yl)propano-ate
1College of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, People's Republic of China.
Abstract:
In the title mol-ecule, C15H21NO5, the dihedral angle between the mean plane of the -N-C(=O)-O- group [maximum deviation = 0.002 (1) Å for the C atom] and the benzene ring is 82.2 (2)°. In the crystal, O-H⋯O and N-H⋯O hydrogen bonds connect the mol-ecules, forming a two-dimensional network parallel to (001).
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