Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nomenclature of Carboxylic Acid Derivatives: Amides and Nitriles01:11

Nomenclature of Carboxylic Acid Derivatives: Amides and Nitriles

4.3K
Naming Amides
The IUPAC and common names of amides are derived from the parent carboxylic acid, by replacing the suffix “oic acid” and “ic acid,” respectively, with “amide.” In the following example, the IUPAC name ethanamide is derived from ethanoic acid, and the common name, acetamide, is obtained from acetic acid.
4.3K
Local Anesthetics: Chemistry and Structure-Activity Relationship01:30

Local Anesthetics: Chemistry and Structure-Activity Relationship

4.9K
Local anesthetics (LAs) are drugs that induce a temporary loss of sensation in a limited body area, preventing pain. Cocaine was the first local anesthetic discovered in the late 19th century. Cocaine is a benzoic acid ester obtained from the leaves of coca shrubs and was often used for its psychotropic effects. Cocaine was first isolated in 1860 by Albert Niemann. Sigmund Freud studied the physiological actions of cocaine. Carl Koller later introduced it into clinical practice in 1884 as a...
4.9K
Acid Halides to Ketones: Gilman Reagent01:14

Acid Halides to Ketones: Gilman Reagent

3.2K
Lithium dialkyl cuprate, also known as Gilman reagents, selectively reduces acid halides to ketones. The acid chloride is treated with Gilman reagent at −78 °C in the presence of ether solution to produce a ketone in good yield.
As shown below, the mechanism proceeds in two steps. First, one of the alkyl groups of the reagent acts as a nucleophile and attacks the acyl carbon of the acid chloride to form a tetrahedral intermediate. This is followed by the reformation of the...
3.2K
Sedatives and Hypnotics Drugs: Miscellaneous Agents01:17

Sedatives and Hypnotics Drugs: Miscellaneous Agents

981
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
981
Local Anesthetics: Common Agents and Their Applications01:23

Local Anesthetics: Common Agents and Their Applications

1.3K
Local anesthetics (LAs) are commonly used for various applications in medical and dental procedures. Some of the common agents used are cocaine, lidocaine, and bupivacaine.
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
1.3K
Benzene to 1,4-Cyclohexadiene: Birch Reduction Mechanism01:18

Benzene to 1,4-Cyclohexadiene: Birch Reduction Mechanism

2.0K
Birch reduction uses solvated electrons as reducing agents. The reaction converts benzene to 1,4-cyclohexadiene. The reaction proceeds by the transfer of a single electron to the ring to form a benzene radical anion. This anion is highly basic—it abstracts a proton from the alcohol to form a cyclohexadienyl radical. Another single electron transfer gives the cyclohexadienyl anion. A proton transfer from the alcohol forms 1,4-cyclohexadiene. Since this reduction occurs via radical anion...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synthesis, structure, Hirshfeld surface analysis, and molecular docking studies of the cocrystal between the Cu(II) complex of salicylic acid and uncoordinated piracetam.

Turkish journal of chemistry·2025
Same author

Nematode-resistance loci in upland cotton genomes are associated with structural differences.

G3 (Bethesda, Md.)·2024
Same author

Synthesis, crystal structure and Hirshfeld surface analysis of di-aqua-bis-(<i>o</i>-phenyl-enedi-amine-κ<sup>2</sup><i>N</i>,<i>N</i>')nickel(II) naphthalene-1,5-di-sulfonate.

Acta crystallographica. Section E, Crystallographic communications·2023
Same author

Crystal structure and Hirshfeld surface analysis of 8-aza-niumylquinolinium tetra-chlorido-zincate(II).

Acta crystallographica. Section E, Crystallographic communications·2023
Same author

Synthesis, crystal structure, Hirshfeld surface analysis and DFT study of the 1,1'-(buta-1,3-diyne-1,4-di-yl)bis-(cyclo-hexan-1-ol).

Acta crystallographica. Section E, Crystallographic communications·2023
Same author

Synthesis, crystal structure and Hirshfeld surface analysis of <i>catena</i>-poly[[bis-(semicarbazide-κ<sup>2</sup> <i>N</i>,<i>O</i>)copper(II)]-μ-sulfato-κ<sup>2</sup> <i>O</i>:<i>O</i>'].

Acta crystallographica. Section E, Crystallographic communications·2022

Related Experiment Video

Updated: May 4, 2026

Syntheses, Crystallization, and Spectroscopic Characterization of 3,5-Lutidine N-Oxide Dehydrate
06:18

Syntheses, Crystallization, and Spectroscopic Characterization of 3,5-Lutidine N-Oxide Dehydrate

Published on: April 24, 2018

7.9K

Lacinilene C 7-methyl ether.

Vyacheslav V Uzbekov1, Samat A Talipov1, Bakhtiyar T Ibragimov1

  • 1A.S. Sadykov Institute of Bioorganic Chemistry, Academy of Sciences of Uzbekistan, Mirzo Ulugbek str. 83, Tashkent 100125, Uzbekistan.

Acta Crystallographica. Section E, Structure Reports Online
|January 16, 2014
PubMed
Summary

A novel sesquiterpene from cotton plants shows promising anti-bacterial properties. Its crystal structure reveals specific molecular arrangements and hydrogen bonding crucial for its biological activity.

More Related Videos

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
12:02

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity

Published on: November 2, 2016

14.4K
Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of &#945;-Imino &#947;-Lactones and Alkylidene Pyrazolones
10:17

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

6.0K

Related Experiment Videos

Last Updated: May 4, 2026

Syntheses, Crystallization, and Spectroscopic Characterization of 3,5-Lutidine N-Oxide Dehydrate
06:18

Syntheses, Crystallization, and Spectroscopic Characterization of 3,5-Lutidine N-Oxide Dehydrate

Published on: April 24, 2018

7.9K
An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
12:02

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity

Published on: November 2, 2016

14.4K
Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of &#945;-Imino &#947;-Lactones and Alkylidene Pyrazolones
10:17

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

6.0K

Area of Science:

  • Natural Product Chemistry
  • Organic Chemistry
  • Crystallography

Background:

  • Sesquiterpenes are a class of terpenes derived from C15 precursors.
  • Cotton plants produce a variety of secondary metabolites with potential bioactivity.
  • Understanding the structure-activity relationship of natural compounds is key to drug discovery.

Purpose of the Study:

  • To isolate and characterize a novel sesquiterpene from cotton plant foliar tissues.
  • To investigate the anti-bacterial properties of the isolated compound.
  • To elucidate the crystal structure and intermolecular interactions of the sesquiterpene.

Main Methods:

  • Isolation and purification of the sesquiterpene from cotton plant extracts.
  • Spectroscopic techniques (e.g., NMR, Mass Spectrometry) for structural elucidation.
  • Single-crystal X-ray diffraction for crystal structure determination.

Main Results:

  • A novel sesquiterpene, 1-hydroxy-7-methoxy-1,6-dimethyl-4-(propan-2-yl)naphthalen-2(1H)-one (C16H20O3), was isolated.
  • The compound exhibits anti-bacterial properties.
  • X-ray crystallography revealed a near-planar phenyl ring and specific orientations of hydroxyl and methyl groups. Inversion dimers formed via O-H⋯O hydrogen bonds, with C-H⋯O bonds linking dimers into columns along the c axis, resulting in a crystal packing factor of 0.66.

Conclusions:

  • The isolated sesquiterpene possesses significant anti-bacterial potential.
  • The detailed crystal structure provides insights into the molecular packing and intermolecular forces.
  • Further research into its anti-bacterial mechanisms and applications is warranted.