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Updated: May 4, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
(2E)-3-(2-Chloro-benzo[h]quinolin-3-yl)-1-(2-methyl-4-phenyl-quinolin-3-yl)prop-2-en-1-one
R Prasath1, S Sarveswari2, Seik Weng Ng3
1Department of Chemistry, BITS, Pilani - K. K. Birla Goa Campus, Goa 403 726, India.
Abstract:
In the title compound, C32H21ClN2O, an almost planar (r.m.s. deviation = 0.033 Å) prop-2-en-1-one bridge links quinolinyl and benzoquinolinyl residues; the latter are twisted out of the plane of the bridge [dihedral angles = 75.94 (5) and 20.20 (5)°, respectively]. In the crystal, a three-dimensional architecture arises as a result of C-H⋯O, C-H⋯π and π-π [centroid-centroid distances involving pyridine rings = 3.5806 (7)-3.7537 (7) Å] interactions.
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