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Updated: May 4, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
6,8-Di-chloro-4-oxochromene-3-carbalde-hyde
Yoshinobu Ishikawa1, Yuya Motohashi1
1School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
Abstract:
The asymmetric unit of the title compound, C10H4Cl2O3, contain two essentially planar independent mol-ecules (mean atomic deviations from the corresponding least-square planes are 0.041 and 0.045 Å for mol-ecules 1 and 2, respectively). In the crystal, mol-ecules are linked through a pair of halogen bonds [Cl⋯O separations are 3.044 (5) and 3.033 (6) Å, C-Cl⋯O angles are 160.4 (3) and 162.8 (3)°, and C=O⋯Cl angles are 138.7 (4) and 139.6 (4)°, respectively, in mol-ecules 1 and 2] and C-H⋯O hydrogen bonds into slightly folded bands [the dihedral angle between the planes of neighboring mol-ecules is 8.6 (2)°] along the c-axis direction.
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