![Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F51444.jpg&w=3840&q=50)
3-Ethyl-cis-2,6-di-phenyl-piperidine
V Maheshwaran1, S Abdul Basheer2, A Akila2
1Centre of Advanced Study in Crystallography and Biophysics, University of Madras, Guindy Campus, Chennai 600 025, India.
Acta Crystallographica. Section E, Structure Reports Online
|January 16, 2014
Summary
The crystal structure of compound C19H23N reveals a piperidine ring in a chair conformation. Phenyl rings are equatorially oriented, with C-H⋯π interactions observed in the crystal lattice.
Area of Science:
- Organic Chemistry
- Crystallography
Background:
- Piperidine derivatives are common scaffolds in medicinal chemistry.
- Understanding the conformational preferences of substituted piperidines is crucial for drug design.
Purpose of the Study:
- To elucidate the three-dimensional structure and intermolecular interactions of the title compound, C19H23N.
- To analyze the conformational behavior of the piperidine ring and its substituents.
Main Methods:
- Single-crystal X-ray diffraction analysis was performed.
- The crystal structure was solved and refined to determine atomic coordinates and bonding information.
Main Results:
- The piperidine ring was found to adopt a chair conformation.
- The phenyl rings at the 2,6-positions of the piperidine ring were observed in equatorial orientations.
- Distinctive C-H⋯π intermolecular interactions were identified within the crystal structure.
Conclusions:
- The study provides detailed structural insights into C19H23N.
- The observed conformation and interactions offer valuable data for structure-activity relationship studies of related compounds.
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