Nuclear DNA recordings in gastric carcinoids. A cytofluorometric study on single tumour cells

Cytofluorometric nuclear DNA analyses were performed on single tumour cells from eight argyrophilic gastric carcinoids. Three tumours displayed grossly diploid DNA values, with a fraction of S-phase cells of 1-8%. Four other tumours were also mainly diploid, but showed an increased number of tetraploid cells, and one tumour was aneuploid with a stem-cell line of triploid cells. These and previous results indicate that gastric carcinoids are relatively heterogenous with respect to their morphology, nuclear DNA profiles and biological behaviour, in contrast to most intestinal "classical" carcinoids. Furthermore, the results are in accordance with the suggestion that gastric carcinoids may represent a highly differentiated variety within a spectrum of neuroendocrine neoplasia analogous to the corresponding variety observed in the bronchus (carcinoid-small cell, undifferentiated carcinoma).