Efficacy and side-effect profiles of lactulose, docusate sodium, and sennosides compared to PEG in opioid-induced constipation: a systematic review
Related Experiment Video
Updated: May 4, 2026

Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation
Published on: July 5, 2024
Teresa Ruston1, Kathleen Hunter2, Greta Cummings2
1Royal Alexandra Hospital, Alberta Thoracic Oncology Program/Chest Medicine Clinic, Room 4505 Children's Centre, Royal Alexandra Hospital, 10240 Kingsway Ave., Edmonton, AB T5H 3V9. Teresa.Ruston@albertahealthservices.ca
Unlabelled:
Opioid-induced constipation (OIC) is a side effect of opioid therapy that can affect quality of life, adherence to treatment, and morbidity and possibly mortality.
Objectives:
To investigate whether docusate sodium, sennosides, and lactulose have equal efficacy and side effect profiles compared to PEG in the management of OIC in adults.
Methods:
A systematic review was undertaken. Randomized controlled trials of adults taking opioids for cancer or non-cancer pain were considered if they met inclusion criteria.
Conclusions:
Statistical pooling was not possible as no studies met inclusion criteria. Large, well-powered, randomized controlled trials are feasible. Standard definitions of OIC would assist with the execution of these studies and contribute to their internal and external validity. Further research is strongly encouraged.
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