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DDQ-mediated oxidative coupling: an approach to 2,3-dicyanofuran (thiophene)
Zheng-Lin Wang1, Hong-Liang Li, Li-Shi Ge
1Shanghai Key Laboratory of New Drug Design & School of Pharmacy, East China University of Science and Technology , 130 Meilong Road, Shanghai 200237, China.
Abstract:
A facile oxidative coupling of α-carbonyl radicals to 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) for the synthesis of 2,3-dicyanofurans and thiophenes starting from readily available β-diketones, simple ketones, and β-keto thioamides in up to 95% yield in one step was developed. Mechanistic investigations revealed that a radical process could be involved in this transformation, and a water promoted C-C bond cleavage pathway is proposed for the formation of 2,3-dicyanofurans and thiophenes.
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