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Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging
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Understanding epigenetic changes in aging stem cells--a computational model approach.

Jens Przybilla1, Thimo Rohlf, Markus Loeffler

  • 1Interdisciplinary Center for Bioinformatics, University Leipzig, Haertelstr. 16-18, 04107, Leipzig, Germany.

Aging Cell
|January 17, 2014
PubMed
Summary

Stem cell aging involves epigenetic changes like DNA methylation and histone modifications, impacting gene expression and cell function. Our model shows stem cell niches slow epigenetic aging, while proliferation accelerates it.

Keywords:
DNA methylationaging of stem cellsclonal competitionhistone modificationmathematical modelpopulation dynamics

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