Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Replicative Cell Senescence02:15

Replicative Cell Senescence

3.0K
3.0K
Replicative Cell Senescence02:15

Replicative Cell Senescence

3.5K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
3.5K
Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

2.1K
Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
2.1K
Epigenetic Regulation01:37

Epigenetic Regulation

3.5K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.5K
Epigenetic Regulation01:46

Epigenetic Regulation

28.7K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
28.7K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.6K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Patient-derived tissue slice cultures from endoscopic biopsies as a translational ex vivo model for inflammatory bowel diseases.

Clinical and experimental medicine·2026
Same author

Development of phenotype algorithms for the detection of adverse events in electronic health record data: a multicentre study.

BMJ open·2026
Same author

A distributed analysis approach for pharmacovigilance data from electronic medical records in German university hospitals: the POLAR_MI ETL Pipeline.

BMC medical informatics and decision making·2026
Same author

Secondary Data for Clinical Pharmacists' Decision Support: Evaluating 'Triple Whammy' Interactions Within INTERPOLAR.

Studies in health technology and informatics·2026
Same author

Detecting Contraindications in Routinely Collected Healthcare Data to Emulate Decision Support for Medication Reviews Within the INTERPOLAR Study.

Studies in health technology and informatics·2026
Same author

<i>Trans</i>-eQTLs reveal the architecture of human gene regulatory networks.

medRxiv : the preprint server for health sciences·2026
Same journal

Bidirectional Relationship and Shared Mechanisms Between Sarcopenia and Osteoporosis: An Observational Study Integrating Genomic, Proteomic, and Metabolomic Data.

Aging cell·2026
Same journal

Clonal Analyses Reveal the Impact of Hematopoietic Stem and Progenitor Cell Aging on T Cell Development.

Aging cell·2026
Same journal

A Gut-Centric View of Ageing: A Pilot Analysis Mapping Age-Associated Immune and Molecular Alterations in Colonic Mucosa Using Spatial Proteomics.

Aging cell·2026
Same journal

Correction to "Environmental Enrofloxacin Exposure as a Modifiable Driver of Mitochondria-Mediated Intestinal Aging and Barrier Dysfunction".

Aging cell·2026
Same journal

Correction to "Social Stress Shortens Lifespan in Mice".

Aging cell·2026
Same journal

A Primate-Specific lncRNA LINC01021 Contributes to Cellular and Organismal Aging via DAZAP1-Dependent Destabilization of RBMX.

Aging cell·2026
See all related articles

Related Experiment Video

Updated: May 4, 2026

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging
09:10

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging

Published on: January 30, 2026

982

Understanding epigenetic changes in aging stem cells--a computational model approach.

Jens Przybilla1, Thimo Rohlf, Markus Loeffler

  • 1Interdisciplinary Center for Bioinformatics, University Leipzig, Haertelstr. 16-18, 04107, Leipzig, Germany.

Aging Cell
|January 17, 2014
PubMed
Summary
This summary is machine-generated.

Stem cell aging involves epigenetic changes like DNA methylation and histone modifications, impacting gene expression and cell function. Our model shows stem cell niches slow epigenetic aging, while proliferation accelerates it.

Keywords:
DNA methylationaging of stem cellsclonal competitionhistone modificationmathematical modelpopulation dynamics

More Related Videos

Combining Magnetic Sorting of Mother Cells and Fluctuation Tests to Analyze Genome Instability During Mitotic Cell Aging in Saccharomyces cerevisiae
11:08

Combining Magnetic Sorting of Mother Cells and Fluctuation Tests to Analyze Genome Instability During Mitotic Cell Aging in Saccharomyces cerevisiae

Published on: October 16, 2014

14.7K
Evaluation of Injury-induced Senescence and In Vivo Reprogramming in the Skeletal Muscle
09:14

Evaluation of Injury-induced Senescence and In Vivo Reprogramming in the Skeletal Muscle

Published on: October 26, 2017

8.9K

Related Experiment Videos

Last Updated: May 4, 2026

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging
09:10

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging

Published on: January 30, 2026

982
Combining Magnetic Sorting of Mother Cells and Fluctuation Tests to Analyze Genome Instability During Mitotic Cell Aging in Saccharomyces cerevisiae
11:08

Combining Magnetic Sorting of Mother Cells and Fluctuation Tests to Analyze Genome Instability During Mitotic Cell Aging in Saccharomyces cerevisiae

Published on: October 16, 2014

14.7K
Evaluation of Injury-induced Senescence and In Vivo Reprogramming in the Skeletal Muscle
09:14

Evaluation of Injury-induced Senescence and In Vivo Reprogramming in the Skeletal Muscle

Published on: October 26, 2017

8.9K

Area of Science:

  • Molecular biology
  • Cell biology
  • Computational biology

Background:

  • Stem cell function declines with age, linked to chromatin changes like histone modifications and DNA methylation.
  • The interplay and environmental influences on these age-associated epigenetic processes remain unclear.

Purpose of the Study:

  • To mechanistically model age-related epigenetic changes in stem cells.
  • To investigate the impact of epigenetic modifications on gene expression and age-related phenotypes.
  • To explore how stem cell niche and proliferation affect epigenetic aging.

Main Methods:

  • Developed a novel computational model combining individual cell-based stem cell population dynamics with epigenetic regulation of transcription.
  • Simulated age-related changes in histone H3 lysine 4 trimethylation and DNA methylation.
  • Analyzed the influence of epigenetic modifier activity on stem cell aging and heterogeneity.

Main Results:

  • Epigenetic aging significantly impacts stem cell heterogeneity.
  • Homing to stem cell niches retards epigenetic aging.
  • Increased stem cell proliferation can lead to progeroid phenotypes.
  • Hematopoietic stem cell (HSC) aging models predict young HSC activation, retarding overall HSC population aging.
  • Variance in histone methyltransferase activity may explain interindividual HSC number variations.

Conclusions:

  • Stem cell aging is driven by complex epigenetic alterations affecting gene expression and cellular phenotypes.
  • Stem cell niches play a protective role against epigenetic aging.
  • The developed model offers insights into stem cell aging mechanisms and heterogeneity, with implications for hematopoietic stem cells.