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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
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Embryonic Stem Cells00:57

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
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Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy
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A global assessment of stem cell engineering.

Jeanne F Loring1, Todd C McDevitt, Sean P Palecek

  • 11 Director, Center for Regenerative Medicine, the Scripps Research Institute , LaJolla, California.

Tissue Engineering. Part A
|January 17, 2014
PubMed
Summary

Engineers are crucial for advancing stem cell engineering (SCE) and driving economic growth. Increased investment and interdisciplinary collaboration are needed to translate SCE research into clinical and commercial success.

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Area of Science:

  • Biotechnology
  • Bioengineering
  • Regenerative Medicine

Background:

  • Stem cell engineering (SCE) integrates engineering principles into stem cell research.
  • Global assessment conducted over two years to evaluate the status and trends in SCE.
  • Sponsored by major scientific and governmental organizations including NSF, NCI, and NIST.

Purpose of the Study:

  • To assess the worldwide status and trends in stem cell engineering.
  • To identify the role of engineers and engineering approaches in basic research and clinical translation.
  • To inform strategies for future growth and development in the field.

Main Methods:

  • Global assessment involving site visits in Asia and Europe.
  • Convened workshops to gather expert input.
  • Managed by the World Technology Evaluation Center.

Main Results:

  • Identified a need for a greater role for engineers and engineering methodologies in SCE.
  • Highlighted the potential for SCE to create new markets and foster economic growth.
  • Emphasized the necessity of increased investment in engineering, applied research, and commercialization.

Conclusions:

  • Enhanced investment in engineering, applied research, and commercialization is vital for SCE.
  • Programs supporting interdisciplinary teams, academic-industry partnerships, and translational models are required.
  • Strategic international partnerships and multinational grant programs are beneficial for leveraging global strengths in SCE.