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Updated: May 4, 2026

Purification and Expansion of Mouse Invariant Natural Killer T Cells for in vitro and in vivo Studies
Published on: February 15, 2021
Switching invariant natural killer T (iNKT) cell response from anticancerous to anti-inflammatory effect: molecular
Xavier Laurent1, Benjamin Bertin, Nicolas Renault
1Faculté de Médecine, Intestinal Biotech Development, Amphis J et K, Boulevard du Professeur Jules Leclerc, 59045 Lille Cedex, France.
Abstract:
Since the discovery in 1995 of α-galactosylceramide 1 (α-GalCer), also known as KRN7000,1 hundreds of compounds have been synthesized in order to activate invariant natural killer T (iNKT) cells. Such keen interest for this lymphocyte cell type is due to its ability to produce different cytokines that bias the immune response toward a Th1 or Th2 profile. Thus, an understanding of the immune polarization mechanism via iNKT activation may pave the way toward new therapeutics in various domains including cancer and infectious and autoimmune diseases. In this review, we propose an up-to-date analysis of iNKT activators associated with a structure-activity relationship (SAR) study aimed at complementing available reviews by highlighting molecular bases for a selective immune response.
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