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Neonatal stroke: a review of the current evidence on epidemiology, pathogenesis, diagnostics and therapeutic options

N E van der Aa1, M J N L Benders, F Groenendaal

  • 1Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.

Acta Paediatrica (Oslo, Norway : 1992)
|January 17, 2014
PubMed

Insights

Neonatal stroke, encompassing perinatal arterial ischaemic stroke and cerebral sinovenous thrombosis, is a significant concern. Despite improved understanding of causes, effective therapeutic options for neonatal stroke remain limited, necessitating further research.

Area of Science:

  • Neurology
  • Pediatrics
  • Neonatology

Background:

  • Neonatal stroke, including perinatal arterial ischaemic stroke and cerebral sinovenous thrombosis, is a critical issue affecting newborns.
  • This condition can lead to significant long-term neurological deficits.

Purpose of the Study:

  • To review the current evidence on the epidemiology, pathogenesis, diagnostics, and therapeutic strategies for neonatal stroke.
  • To highlight the unmet need for effective treatments.

Main Methods:

  • Systematic review of existing literature on neonatal stroke.
  • Analysis of data concerning incidence, causes, diagnostic methods, and treatment approaches.

Main Results:

  • Epidemiological data and insights into pathogenesis have advanced.
  • Current diagnostic tools provide a basis for identifying neonatal stroke.
  • However, significant limitations exist in available therapeutic options.

Conclusions:

  • While understanding of neonatal stroke mechanisms and risk factors has grown, therapeutic advancements are lacking.
  • Given the high rate of neurological sequelae, developing effective treatments for neonatal stroke is a priority for future research.
Abstract

Keywords:
Cerebral sinovenous thrombosisMRINeonatal stroke

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