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Published on: September 20, 2024
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Clusterin expression level correlates with increased oxidative stress in asthmatics.
Hyouk-Soo Kwon1, Tae-Bum Kim1, Yoon Su Lee1
1Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Summary
Clusterin, a marker of oxidative stress, is elevated in severe asthma and decreases with treatment. This suggests clusterin may help assess asthma severity and airway inflammation.
Area of Science:
- Biochemistry
- Immunology
- Pulmonology
Background:
- Oxidative stress is implicated in asthma pathogenesis.
- Clusterin acts as a cellular biosensor for oxidative stress and possesses antioxidant properties.
- The role of clusterin in asthma remains under-investigated.
Purpose of the Study:
- To determine if oxidative stress regulates clusterin expression in asthma patients.
- To evaluate clusterin as a potential biomarker for assessing response to inhaled corticosteroids.
Main Methods:
- Clusterin levels were measured in serum, sputum, and peripheral blood mononuclear cells (PBMCs) using ELISA and Western blotting.
- Pulmonary function and hyperoxidized peroxiredoxin (a marker of oxidative stress) expression were assessed.
- Serum clusterin was compared in treatment-naive asthma patients before and after inhaled corticosteroid therapy.
Main Results:
- Serum clusterin was significantly higher in severe asthma patients, inversely correlating with pulmonary function.
- Increased hyperoxidized peroxiredoxin expression in PBMCs strongly correlated with clusterin levels.
- Serum clusterin concentrations decreased significantly after inhaled corticosteroid treatment in naive patients.
Conclusions:
- Clusterin may serve as a biomarker for asthma severity and oxidative stress burden.
- Clusterin shows potential for rapid assessment of airway inflammation in asthma patients.
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