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Global Level Quantification of Histone Post-Translational Modifications in a 3D Cell Culture Model of Hepatic Tissue
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Cracking the survival code: autophagy-related histone modifications.

Jens Füllgrabe1, Nina Heldring2, Ola Hermanson3

  • 1Department of Oncology Pathology; Cancer Centrum Karolinska; Karolinska Institutet; Stockholm, Sweden.

Autophagy
|January 17, 2014
PubMed
Summary

Histone modifications regulate cell death and survival. This review explores the "autophagic histone code," highlighting how these protein changes influence the cell

Keywords:
EHMT2/G9aHATHDACHDMHMTKAT8/hMOF/MYST1SUV420H2histone codehistone posttranslational modifications

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Area of Science:

  • Cellular biology
  • Molecular biology
  • Epigenetics

Background:

  • Histones are key protein components of chromatin.
  • Histone modifications are critical regulators of cellular life and death.
  • The "apoptotic histone code" is established, but the role in autophagy is emerging.

Purpose of the Study:

  • To describe the emerging "autophagic histone code."
  • To review the role of histone modifications in the cellular life vs. death decision.

Main Methods:

  • Literature review
  • Synthesis of current research on histone modifications and autophagy

Main Results:

  • Histone modifications play a significant role in regulating autophagy.
  • Emerging evidence points to an "autophagic histone code."

Conclusions:

  • Histone modifications are crucial in determining cell fate, influencing both apoptosis and autophagy.
  • Understanding the "autophagic histone code" is vital for comprehending cellular survival mechanisms.