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A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s
Published on: September 25, 2017
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Natural nitriles and their metabolism.
J L Legras1, G Chuzel, A Arnaud
1ENSA-INRA, Place Viala, 34060, Montpellier Cedex, France.
World Journal of Microbiology & Biotechnology
|January 17, 2014
Summary
This review covers toxic nitrile compounds like cyanogenic glycosides and cyanolipids found in nature. It highlights microbial detoxification methods for food safety.
Area of Science:
- Biochemistry
- Toxicology
- Food Science
Background:
- Nitrile compounds, including cyanogenic glycosides and cyanolipids, are prevalent in natural sources like plants and animals.
- These compounds can pose toxicity risks in food and foodstuff.
- Various other aromatic and aliphatic nitriles are also synthesized, though less commonly.
Purpose of the Study:
- To review naturally occurring nitrile compounds and their toxicological significance.
- To explore the synthesis and degradation pathways of these compounds.
- To emphasize the role of microorganisms in detoxifying nitrile-contaminated food.
Main Methods:
- Literature review of existing studies on nitrile compounds.
- Analysis of synthesis and degradation processes.
- Evaluation of microbial detoxification strategies.
Main Results:
- Identification of cyanogenic glycosides and cyanolipids as widespread toxic nitriles.
- Overview of the synthesis and degradation mechanisms of these natural toxins.
- Demonstration of microbial potential for nitrile detoxification in food.
Conclusions:
- Nitrile compounds represent a significant toxicological concern in natural products.
- Understanding nitrile metabolism is crucial for food safety.
- Microbial detoxification offers a promising approach for mitigating nitrile toxicity in food and foodstuff.
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