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Updated: May 4, 2026
07:41
Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
Published on: May 17, 2019
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ARID1A: a potential prognostic factor for breast cancer
Jing Zhao1, Caigang Liu, Zuowei Zhao
1Gastrointestinal Tumor Pathology Laboratory of Cancer Institute, the First Hospital of China Medical University, Shenyang, China, 110001.
Summary
Loss of BAF250a protein expression in breast cancer correlates with advanced disease characteristics. This protein
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- Breast cancer remains a leading cause of cancer-related mortality worldwide.
- Understanding molecular markers associated with breast cancer progression is crucial for improving patient outcomes.
Purpose of the Study:
- To investigate the expression of BAF250a protein in breast cancer tissues.
- To analyze the association between BAF250a expression and clinicopathological features.
- To evaluate the prognostic significance of BAF250a in breast cancer patients.
Main Methods:
- Western blot analysis and immunohistochemical staining were used to detect BAF250a protein expression in 496 breast cancer specimens.
- Statistical analyses, including t-tests, correlation analyses, and Cox regression, were employed to assess relationships.
Main Results:
- BAF250a protein expression was significantly lower in breast cancer tissues compared to normal tissues.
- Loss of BAF250a expression correlated with higher histological grade, lymph node metastasis, advanced TNM stage, and altered ER, PR, c-erbB-2, and p53 status.
- Patients with BAF250a expression had significantly better disease-specific survival.
Conclusions:
- BAF250a protein expression loss is associated with aggressive clinicopathological features in breast cancer.
- BAF250a deletion is an independent prognostic factor for poor survival in breast cancer.
- BAF250a represents a potential therapeutic target for breast cancer treatment.
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