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[Non-specific histamine liberation and propofol].
Annales Francaises D'Anesthesie Et De Reanimation
|January 1, 1987
Summary
Propofol anesthesia did not trigger histamine release in patients at risk. This study monitored blood pressure, heart rate, and histamine levels after propofol or thiopentone administration.
Area of Science:
- Anesthesiology
- Pharmacology
Background:
- Histamine release is a potential adverse effect of anesthetic agents.
- Patients at risk require careful monitoring during anesthesia induction.
Purpose of the Study:
- To evaluate the potential of propofol to induce histamine release in at-risk patients.
- To compare histamine release between propofol and thiopentone.
Main Methods:
- 40 at-risk patients received either propofol (2.5 mg/kg) or thiopentone (7 mg/kg).
- Blood pressure, heart rate, and plasma histamine levels were measured pre- and post-administration.
- Patients were premedicated with terfenadine (anti-H1 antagonist).
- Histamine was quantified using radio-immunology.
Main Results:
- A transient 20% decrease in blood pressure occurred in both groups.
- No significant changes in heart rate or plasma histamine levels were observed.
- Minor histamine release signs were noted in a few patients in both groups.
Conclusions:
- Propofol, when administered over 60 seconds, does not appear to induce significant non-specific histamine release in at-risk patients.
- Both propofol and thiopentone caused similar, transient hypotension.
- Premedication with an anti-H1 antagonist may mitigate histamine-related adverse effects.