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Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...

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Updated: May 4, 2026

Multiplexed Fluorescent Microarray for Human Salivary Protein Analysis Using Polymer Microspheres and Fiber-optic Bundles

Multiplexed Fluorescent Microarray for Human Salivary Protein Analysis Using Polymer Microspheres and Fiber-optic Bundles

Published on: October 10, 2013

Multiplexed protein analysis.

Yesim Gökmen-Polar¹, Sunil Badve

¹Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Science Translational Medicine

|January 17, 2014

Summary

This summary is machine-generated.

Multiplexed protein analysis using antibody-DNA barcoding offers a new way to find cancer biomarkers. This method can speed up the early detection and monitoring of cancer in patients.

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Area of Science:

Biochemistry
Molecular Biology
Oncology

Background:

Early cancer detection and monitoring are crucial for effective treatment.
Current methods for biomarker analysis can be time-consuming and limited in scope.

Purpose of the Study:

To introduce and evaluate a novel antibody-DNA barcoding approach for multiplexed protein analysis.
To demonstrate the potential of this technique for accelerating cancer biomarker discovery and monitoring.

Main Methods:

Development of an antibody-DNA barcoding system for simultaneous detection of multiple proteins.
Application of the multiplexed assay to patient samples for biomarker analysis.

Main Results:

The antibody-DNA barcoding method enables high-throughput, simultaneous detection of various protein biomarkers.
The approach shows promise for efficient and rapid analysis of cancer-related proteins.

Conclusions:

Multiplexed protein analysis via antibody-DNA barcoding represents a significant advancement in cancer biomarker research.
This technique has the potential to revolutionize early cancer detection and patient monitoring strategies.