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The Utility of the Platelet-Lymphocyte Ratio for Predicting No Reflow in Patients With ST-Segment Elevation

Abdulkadir Yildiz1, Murat Yuksel2, Mustafa Oylumlu2

  • 1Department of Cardiology, Dicle University School of Medicine, Diyarbakir, Turkey drakadiryildiz@gmail.com.

Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
|January 17, 2014
PubMed

Insights

High preprocedural platelet-lymphocyte ratio (PLR) and neutrophil-lymphocyte ratio (NLR) predict no reflow after primary percutaneous intervention for ST-elevation myocardial infarction. These inflammatory markers are significant independent predictors of adverse outcomes.

Area of Science:

  • Cardiology
  • Hematology
  • Biomarkers

Background:

  • No reflow is a complication of primary percutaneous intervention (PCI) for ST-elevation myocardial infarction (STEMI).
  • Predictive markers for no reflow are crucial for patient management.
  • Inflammatory markers may play a role in no reflow development.

Purpose of the Study:

  • To evaluate the utility of the preprocedural platelet-lymphocyte ratio (PLR) in predicting no reflow.
  • To assess the association between PLR and no reflow in patients undergoing primary PCI for STEMI.

Main Methods:

  • Retrospective assessment of thrombolysis in myocardial infarction (TIMI) flow grades in 287 patients.
  • Patients were stratified into tertiles based on preprocedural PLR.
  • Multivariate analysis was performed to identify independent predictors of no reflow.

Main Results:

  • No reflow incidence was significantly higher in higher PLR tertiles (43 patients) compared to lower tertiles (6 patients).
  • Preprocedural PLR and neutrophil-lymphocyte ratio (NLR) were significant independent predictors of no reflow.
  • Cutoff values of PLR (160) and NLR (5.9) demonstrated good sensitivity and specificity for predicting no reflow.

Conclusions:

  • High preprocedural PLR and NLR are significant and independent predictors of no reflow.
  • These inflammatory markers can aid in identifying patients at higher risk for no reflow after primary PCI.
  • Further research may explore therapeutic strategies targeting these inflammatory pathways.

Keywords:
acute ST-segment elevation myocardial infarctionno reflowplatelet to lymphocyte ratioprimary percutaneous coronary intervention

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