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The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
Published on: August 2, 2017
Placental growth factor: as an early second trimester predictive marker for preeclampsia in normal and high-risk
Necmiye Dover1, Hacer C Gulerman1, Sevki Celen1
1Department of Perinatology, Zekai Tahir Burak Women's Health Education and Research Hospital, Talatpaşa Bulvarı, Samanpazarı, Ankara, Turkey.
Objective:
Placental growth factor (PlGF) is an angiogenetic factor and inducts the development of preeclampsia in a hypoxic environment. In this study, we examined maternal blood PlGF levels in a pregnant population between 16 and 19 weeks of gestation for determining the prospective value for early diagnosis of preeclampsia as a screening test.
Materials And Methods:
In this prospective cross-sectional study, 114 nulliparous normotensive pregnant women were selected for the control group and 34 patients who have chronic hypertension or had a medical history of hypertensive disorders in previous pregnancies were selected for the study group.
Results:
In the study group, the risk of preeclampsia increased 3.2 times when compared with the control with a confidence interval of 95 %. The cut-off value for PlGF for discriminating preeclamptic and non-preeclamptic patients was found to be 62.5 pg/ml.
Conclusion:
Patients with a medical history of hypertensive disorders and low PIGF levels in early second trimester have an increased risk for preeclampsia.
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