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Related Experiment Video

Updated: May 4, 2026

Mechanical Micronization of Lipoaspirates for Regenerative Therapy
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Post-facelift flap necrosis treatment using charged polystyrene microspheres.

Oren Weissman1, Nimrod Farber1, Eric Remer1

  • 1Department of Plastic and Reconstructive Surgery, Sheba Medical Center, Tel Hashomer, Affiliated to Sackler School of Medicine;

The Canadian Journal of Plastic Surgery = Journal Canadien De Chirurgie Plastique
|January 17, 2014
PubMed
Summary

Charged polystyrene microspheres (Polyheal-1) show promise in accelerating wound healing for post-rhytidectomy flap necrosis. This novel treatment demonstrated faster re-epithelialization and granulation tissue formation in a small patient group.

Keywords:
Charged polystyrene microspheresFace-lift complicationsFlap necrosisOpen wound

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Area of Science:

  • Plastic Surgery
  • Wound Healing Research
  • Biomaterials Science

Background:

  • Flap necrosis is a significant complication after facial rhytidectomy.
  • Effective treatments to speed wound healing and re-epithelialization are needed.

Purpose of the Study:

  • To evaluate the efficacy of charged polystyrene microspheres (Polyheal-1) in treating post-rhytidectomy flap necrosis.
  • To assess wound healing and re-epithelialization rates in open wounds.

Main Methods:

  • Three female patients with post-rhytidectomy flap necrosis and open wounds were treated.
  • Dressings soaked with Polyheal-1 were applied to the wounds.
  • Wound closure rates were monitored.

Main Results:

  • Accelerated granulation tissue formation was observed.
  • Rapid re-epithelialization rates were documented.
  • No adverse events or complications were reported.

Conclusions:

  • Charged polystyrene microspheres (Polyheal-1) may provide an effective new treatment for open wounds from facial rhytidectomy flap necrosis.
  • Further investigation with larger cohorts is recommended to confirm these preliminary findings.