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Updated: May 4, 2026

An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function
Published on: May 4, 2021
Bacterial translocation - impact on the adipocyte compartment
Tassilo Kruis1, Arvind Batra1, Britta Siegmund1
1Department of Medicine I (Gastroenterology, Rheumatology, Infectious Diseases), Charité - Universitätsmedizin Berlin , Berlin , Germany.
Mesenteric fat tissue, through adipokines like leptin, plays a key role in intestinal inflammation, particularly in Crohn's disease. This interaction involves bacterial translocation and immune cell direction.
Area of Science:
- Immunology
- Gastroenterology
- Endocrinology
Background:
- Adipokines and fat tissue regulate the immune system.
- Leptin, an adipokine, has pro-inflammatory functions in intestinal inflammation.
- Crohn's disease (CD) exhibits mesenteric fat hypertrophy ('creeping fat').
Purpose of the Study:
- To review stimuli and mechanisms of fat tissue activation and adipokine release in intestinal inflammation.
- To explore the role of mesenteric fat tissue in Crohn's disease.
- To present a working model of mesenteric fat-immune system interaction.
Main Methods:
- Literature review focusing on mesenteric fat, adipokines, and intestinal inflammation.
- Analysis of mechanisms of adipocyte activation and mediator release.
- Examination of immune cell infiltration in response to fat tissue changes.
Main Results:
- Adipocyte activation is influenced by bacterial translocation.
- Activated adipocytes release mediators affecting local tissue and immune cells.
- Mesenteric fat contributes to the inflammatory process in Crohn's disease.
Conclusions:
- Mesenteric fat actively participates in intestinal inflammation.
- Adipocytes directly interact with the immune system.
- A model of interaction between bacterial translocation, adipocytes, and immune cells is proposed.
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