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[Particles with retrovirus appearance and reverse transcriptase activity in cell cultures derived from lymph node
J Lesser1, D Dormont, J M Tourani
1Division de Radiobiologie et Radioprotection, Centre de Recherches du Service de Santé des Armées, Clamart.
Abstract:
Long term cultures of Reed-Sternberg like cells were obtained from lymph node biopsies of two patients suffering from Hodgkin's disease. As soon as the 15th day of culture, a weak magnesium-dependent reverse transcriptase activity was observed in the cell culture supernatants. Retroviral-like particles were observed in cell cultures as well as in their supernatants.