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Related Experiment Video

Updated: May 4, 2026

Utilization of Plasmonic and Photonic Crystal Nanostructures for Enhanced Micro- and Nanoparticle Manipulation
09:29

Utilization of Plasmonic and Photonic Crystal Nanostructures for Enhanced Micro- and Nanoparticle Manipulation

Published on: September 27, 2011

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Single nanoparticle detection using photonic crystal enhanced microscopy.

Yue Zhuo1, Huan Hu, Weili Chen

  • 1Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA. bcunning@illinois.edu.

The Analyst
|January 17, 2014
PubMed
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Npj biosensing·2026

This study introduces a label-free biosensor using photonic crystals to detect individual nanoparticles. This imaging approach enables precise detection of nanoparticle attachment for advanced biosensing applications.

Area of Science:

  • Nanotechnology
  • Biophotonics
  • Surface Science

Background:

  • Label-free biosensing is crucial for real-time biological detection.
  • Photonic crystals offer unique optical properties for sensing applications.
  • Imaging individual nanoparticle adsorption is challenging but vital for high-sensitivity detection.

Purpose of the Study:

  • To develop and demonstrate a label-free biosensor imaging approach for detecting individual nanoparticle attachment.
  • To utilize photonic crystal surfaces for localized optical measurements.
  • To enable single-nanoparticle imaging for potential single-molecule biosensing.

Main Methods:

  • Utilized a photonic crystal (PC) surface for nanoparticle detection.
  • Employed a microscopy-based approach to scan PC resonant reflection properties.

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Related Experiment Videos

Last Updated: May 4, 2026

Utilization of Plasmonic and Photonic Crystal Nanostructures for Enhanced Micro- and Nanoparticle Manipulation
09:29

Utilization of Plasmonic and Photonic Crystal Nanostructures for Enhanced Micro- and Nanoparticle Manipulation

Published on: September 27, 2011

11.5K
Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment
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Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment

Published on: April 4, 2017

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Trapping of Micro Particles in Nanoplasmonic Optical Lattice
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Trapping of Micro Particles in Nanoplasmonic Optical Lattice

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  • Achieved 0.6 μm spatial resolution for imaging surface attachment.
  • Supported experimental results with finite-difference time-domain (FDTD) simulations.

    • Main Results:

    • Successfully detected individual dielectric and metal nanoparticles via localized shifts in resonant wavelength and reflection magnitude.
    • Observed that metal nanoparticles induce localized reduction in reflection efficiency due to strong absorption.
    • Demonstrated detection through modulation of the resonant wavelength.
    • Validated single-nanoparticle imaging capabilities experimentally and computationally.

    Conclusions:

    • The developed photonic crystal biosensor enables label-free imaging of individual nanoparticle surface adsorption.
    • This technique provides a pathway for single-molecule biosensing by functionalizing nanoparticles as tags.
    • The high-resolution imaging capability opens new avenues in sensitive biological detection.