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[Vascular stiffness and diastolic heart failure]

O M Drapkina, A N Kaburova

    Terapevticheskii Arkhiv
    |January 18, 2014
    PubMed

    Insights

    Vascular stiffness, driven by aging and hypertension, elevates cardiovascular event risk. This review explores its role in heart failure with preserved ejection fraction and potential treatments.

    Area of Science:

    • Cardiovascular physiology and pathophysiology.
    • Vascular biology and aging.
    • Heart failure research.

    Context:

    • Vascular stiffness is a consequence of aging, hypertension, and other risk factors.
    • Increased arterial stiffness leads to central hemodynamic alterations.
    • These changes contribute to left ventricular hypertrophy and diastolic dysfunction.

    Purpose:

    • To review the mechanisms underlying vascular stiffness.
    • To elucidate the role of vascular stiffness in chronic heart failure with preserved ejection fraction (HFpEF).
    • To discuss potential pathogenetic treatments for vascular stiffness-related HFpEF.

    Summary:

    • Vascular stiffness results from degenerative processes and risk factors like aging and hypertension.
    • It causes central hemodynamic changes, increasing left ventricular workload and leading to hypertrophy and diastolic dysfunction.
    • The review focuses on vascular stiffness's contribution to HFpEF and its targeted therapeutic strategies.

    Impact:

    • Highlights the link between vascular stiffness and HFpEF development.
    • Identifies potential therapeutic targets for managing HFpEF.
    • Provides insights into the pathogenetic mechanisms of cardiovascular disease progression.

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