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Updated: May 4, 2026
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A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
Published on: October 2, 2018
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Ovarian hyperstimulation syndrome in systemic amyloidosis
Andrea Piccin1, Norberto Vezzali, Norbert Pescosta
1Haematology Department, San Maurizio Regional Hospital , Bolzano, South Tyrol , Italy .
Summary
Amyloidosis patients undergoing hormonal follicle stimulation for oocyte preservation may face a risk of severe venous thrombosis. This case highlights potential complications of fertility treatments in specific patient populations.
Area of Science:
- Reproductive Endocrinology
- Hematology
- Vascular Medicine
Background:
- Amyloidosis is a rare disease characterized by protein buildup.
- Hormonal follicle stimulation therapy is used for oocyte preservation.
- Venous thrombosis is a serious condition involving blood clots in veins.
Observation:
- A young woman with amyloidosis received hormonal follicle stimulation therapy.
- She subsequently developed severe portal and splenic venous thrombosis.
Findings:
- The temporal association suggests a potential link between the therapy and thrombosis in this patient.
- Amyloidosis may increase susceptibility to thrombotic events during hormonal stimulation.
Implications:
- Clinicians should consider the risk of venous thrombosis in amyloidosis patients undergoing fertility treatments.
- Further research is needed to elucidate the mechanisms and confirm this association.
- This case underscores the importance of careful patient selection and monitoring during assisted reproductive technologies.
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