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Related Experiment Video

Updated: May 3, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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Histamine in migraine and brain.

Karl B Alstadhaug1

  • 1Department of Neurology, Nordland Hospital Trust, Bodø, Norway; Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway.

Headache
|January 18, 2014
PubMed
Summary

The brain

Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Histamine's role in health and disease has been studied for a century.
  • Its vasodilative effects suggested early involvement in migraine pathophysiology.
  • Recent research highlights histamine as a central nervous system neurotransmitter.

Purpose of the Study:

  • To discuss the potential role of the brain's histaminergic system in migraine.
  • To review current understanding of histamine's central nervous system functions in relation to migraine.

Main Methods:

  • Unstructured literature search.
  • No specific hypothesis-driven approach was used.

Main Results:

  • Systemic histamine can elicit, maintain, and aggravate headaches, but does not cross the blood-brain barrier (BBB).
Keywords:
antihistaminechronobiologyhistaminehypothalamusmigrainepathophysiology

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  • Circulating histamine may affect hypothalamic activity via circumventricular organs lacking a BBB.
  • Histamine H3 and H4 receptor ligands may offer prophylactic benefits for migraine, though evidence is limited.

    • Conclusions:

    • The central histaminergic system's role in migraine is largely unexplored.
    • Preclinical findings suggest potential links between the histaminergic system and migraine pathophysiology.
    • Histamine H3 and H4 receptor ligands show potential for migraine prophylaxis, but require further investigation.