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Pharmaceutical applications of graphene-based nanosheets
Mi-Gyeong Kim, Joo Y Park, Yuna Shon
1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Daehak-dong, Gwanak-gu, Seoul 151-742, Republic of Korea. shimg@snu.ac.kr.
Current Pharmaceutical Biotechnology
|January 18, 2014
Summary
Graphene-based nanosheets (GNS) show promise for drug delivery and cancer therapy due to their unique properties. However, challenges like poor stability and toxicity hinder their widespread pharmaceutical application.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Graphene-based nanosheets (GNS) are atomic-thickness carbon monolayers with unique properties.
- GNS offer large surface areas and tunable functional groups, suitable for drug loading.
- Their optical absorption of near-infrared light enables thermal therapies.
Purpose of the Study:
- To review current pharmaceutical applications of GNS.
- To focus on chemotherapy, phototherapy, combination therapy, and theranostics.
- To highlight challenges limiting GNS pharmaceutical use.
Main Methods:
- Literature review of GNS in pharmaceutical applications.
- Analysis of GNS properties relevant to drug delivery and therapy.
- Discussion of challenges including stability, uptake, toxicity, and standardization.
Main Results:
- GNS can be loaded with anticancer drugs via various interactions.
- GNS are applicable in chemotherapy, photodynamic therapy, photothermal therapy, and theranostics.
- Key challenges include poor stability, undefined cellular uptake, toxicity, and lack of standardized preparation.
Conclusions:
- GNS possess significant potential for pharmaceutical and biomedical applications.
- Addressing current limitations is crucial for advancing GNS in medicine.
- Further research is needed for standardized preparation and overcoming toxicity issues.
