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Related Experiment Video

Updated: May 3, 2026

Measuring Local Anaphylaxis in Mice
07:49

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

19.1K

Idiopathic anaphylaxis.

Phil L Lieberman1

  • 1Divisions of Allergy and Immunology, Departments of Medicine and Pediatrics, University of Tennessee, College of Medicine Memphis, Tennessee, USA.

Allergy and Asthma Proceedings
|January 18, 2014
PubMed
Summary
This summary is machine-generated.

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Idiopathic anaphylaxis, often frustrating for patients, is increasingly diagnosed due to advances like mast cell disorders and galactose-alpha-1,3-galactose allergy. Management focuses on avoiding triggers and supportive care, leading to a generally benign prognosis.

Area of Science:

  • Allergy and Immunology
  • Clinical Medicine

Background:

  • Idiopathic anaphylaxis affects up to 60% of patients presenting with anaphylaxis.
  • It is characterized by spontaneous, unprovoked episodes, causing significant patient distress.
  • Idiopathic anaphylaxis is more prevalent in adult women.

Purpose of the Study:

  • To review the medical literature on idiopathic anaphylaxis.
  • To present a diagnostic, preventive, and treatment strategy for idiopathic anaphylaxis episodes.

Main Methods:

  • A literature review was conducted.
  • PubMed was searched using the keywords "idiopathic anaphylaxis".

Main Results:

  • Symptoms are indistinguishable from other anaphylaxis causes; somatoform reactions are a key differential diagnosis.

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Last Updated: May 3, 2026

Measuring Local Anaphylaxis in Mice
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  • Recent advances include identifying mast cell-activating syndromes, systemic mastocytosis, and IgE to galactose-alpha-1,3-galactose as causes.
  • Most cases follow a benign course with diminishing reaction frequency over time.

    • Conclusions:

    • Recent discoveries have enabled identification of causes for previously "idiopathic" anaphylaxis.
    • Management strategies aim to prevent mortality and minimize impact on quality of life.
    • Patients should avoid medications that could exacerbate reactions.