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Related Concept Videos

Bone Disorders01:29

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Age-related changes in mouse bone permeability.

Naiara Rodriguez-Florez1, Michelle L Oyen2, Sandra J Shefelbine3

  • 1Department of Bioengineering, Imperial College London, London SW7 2AZ, UK.

Journal of Biomechanics
|January 18, 2014
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This summary is machine-generated.

Bone

Keywords:
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Area of Science:

  • Biomedical Engineering
  • Skeletal Biology
  • Materials Science

Background:

  • Lacunar-canalicular permeability is crucial for bone's mechanical sensing and adaptation.
  • Existing permeability estimates vary widely, and age-related changes in non-osteonal bone are uncharacterized.
  • Understanding bone fluid flow is key to mechano-transduction and remodeling processes.

Purpose of the Study:

  • To characterize age-related lacunar-canalicular permeability in murine bone using a poroelastic nanoindentation approach.
  • To investigate how different nanoindenter tip sizes affect permeability measurements in aging bone.
  • To establish a reliable method for measuring bone intrinsic permeability.

Main Methods:

  • Poroelastic analysis of nanoindentation data from murine tibiae (2, 7, 12 months old).
  • Utilized two spherical fluid indenter tips (R=238 μm and 500 μm) on embedded bone samples.
  • Measured lacunar-canalicular permeability as a function of age and indenter tip size.

Main Results:

  • Lacunar-canalicular permeability decreased significantly between 2 and 7 months, stabilizing from 7 to 12 months.
  • Larger indenter tips sampled broader permeability ranges, influenced by vascular permeability in older bone.
  • Smaller indenter tips provided more accurate measurements of intrinsic bone permeability, unaffected by age-related variations.

Conclusions:

  • The small nanoindenter tip effectively measured age-related changes in lacunar-canalicular permeability.
  • Larger tips introduced artifacts, indicating the need for careful tip selection in permeability studies.
  • This research enhances understanding of bone fluid flow's role in mechano-transduction and age-related bone adaptation.