[Clinicopathologic characteristics of sporadic renal hemangioblastoma]
Jing Guo1, Liang Li2, Li-hua Zhao
1Department of Pathology, Affiliated Hospital of Jining Medical University, Jining 272029, China.
Objective:
To investigate the clinicopathological characteristics of sporadic renal hemangioblastoma.
Methods:
Two cases of sporadic renal hemangioblastoma were studied by histological and immunohistochemical staining, along with review of the literature.
Results:
Both cases were presented with a renal mass during annual physical examination with an age of 40 and 45 years, respectively. The lesions located in the middle portion of the kidney with a sharp tumor border. Histopathologically, the tumors were characterized by two major components: capillary and stromal cells. Immunohistochemically, the stromal cells were positive for vimentin, NSE, S-100 protein and inhibin-α, and negative for CK, HMB45, Melan A, EMA, CD56 and syn. Both tumors showed a very low level of Ki-67 labeling. The endothelial cells were positive for CD34.
Conclusion:
Sporadic renal hemangioblastoma is a rare benign neoplasm, the diagnosis of which is based on the characteristic follicular architecture and an exclusion of other carcinomas of the kidney.
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