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Complement System

Complement System

The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...

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Updated: May 3, 2026

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Published on: January 30, 2014

Soluble complement complex C5b-9 promotes microglia activation.

Chao Yang¹, Li Yang², Yong Liu¹

¹Department of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.

Journal of Neuroimmunology

|January 18, 2014

Summary

This summary is machine-generated.

Soluble C5b-9 activates microglia, the central nervous system

Keywords:

Activation C5b-9 Microglia

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Area of Science:

Neuroimmunology
Complement system biology

Background:

Microglia are key immune cells in the central nervous system (CNS).
Soluble C5b-9 is a pro-inflammatory mediator, but its role in microglia is understudied.

Purpose of the Study:

To investigate the functional role of soluble C5b-9 in microglia activation.

Main Methods:

Treatment of microglia with assembled functional C5b-9.
Analysis of microglia activation markers and cytokine secretion.

Main Results:

Soluble C5b-9 promotes microglia activation.
Up-regulation of costimulatory molecules observed.
Increased cytokine secretion by microglia.

Conclusions:

Soluble C5b-9 exhibits immunoregulatory potential on microglia.
This finding sheds light on the role of the complement system in neuroinflammation.