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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
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iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
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Related Experiment Video

Updated: May 3, 2026

Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology
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Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology

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Stem cells and kidney regeneration.

Yu-Hsiang Chou1, Szu-Yu Pan2, Chian-Huei Yang3

  • 1Renal Division, Department of Internal Medicine, National Taiwan University Hospital, Yun-Lin Branch, Yun-Lin County, Taiwan; Graduate Institute of Physiology, College of Medicine, National Taiwan University, Taipei, Taiwan; Renal Division, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

Journal of the Formosan Medical Association = Taiwan Yi Zhi
|January 18, 2014
PubMed
Summary
This summary is machine-generated.

Regenerating damaged kidney tissue is crucial for slowing chronic kidney disease progression. Advances in stem cells and cell reprogramming offer promising new avenues for kidney regeneration medicine.

Keywords:
bioengineered kidneyendothelial progenitor cellkidney regenerationrenal progenitor cellstem cell

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Epithelial Cell Repopulation and Preparation of Rodent Extracellular Matrix Scaffolds for Renal Tissue Development
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Area of Science:

  • Nephrology
  • Regenerative Medicine
  • Biotechnology

Background:

  • Kidney disease presents a growing global health challenge.
  • Limited inherent renal regenerative capacity necessitates therapeutic interventions.
  • Understanding renal development and reprogramming fuels novel regenerative strategies.

Purpose of the Study:

  • To review recent advancements in kidney regeneration.
  • To explore the potential of various cell types and stem cells in renal repair.
  • To discuss strategies for improving pharmacological and biotechnological approaches to kidney regeneration.

Main Methods:

  • Review of literature on kidney regeneration.
  • Analysis of studies involving manipulation of renal tubular cells, fibroblasts, endothelial cells, and macrophages.
  • Examination of applications of bone marrow-derived cells, mesenchymal stem cells, embryonic stem cells, and induced pluripotent stem cells.
  • Discussion of endogenous and reprogrammed renal progenitor cells.
  • Evaluation of the role of angiogenesis in ameliorating renal hypoxia and fibrosis.

Main Results:

  • Significant progress has been made in manipulating various renal cell types for regenerative purposes.
  • Diverse stem cell populations show potential for application in renal regeneration.
  • Reprogrammed renal progenitor cells offer a promising source for differentiating into multiple renal cell types.
  • Angiogenesis emerges as a key factor in mitigating renal hypoxia and fibrosis.

Conclusions:

  • Targeted manipulation of renal cells and stem cell therapies are advancing kidney regeneration.
  • Reprogrammed progenitor cells and enhanced angiogenesis hold significant promise for future kidney repair.
  • Further development of pharmacological and biotechnological methods is essential for effective kidney regeneration medicine.