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Updated: May 3, 2026

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
Published on: April 4, 2025
Assembly of chemically modified G-rich sequences into tetramolecular DNA G-quadruplexes and higher order structures
Jun Zhou1, Frédéric Rosu2, Samir Amrane1
1Univ. Bordeaux, ARNA Laboratory, F-33000 Bordeaux, France; INSERM, U869, IECB, F-33600 Pessac, France.
Abstract:
In this review, we introduce the biophysical and biochemical methods currently used to investigate the structures and stabilities of tetramolecular DNA G-quadruplexes containing chemical modifications. We hope this paper will guide others as they perform similar experiments leading to more information about the effects of chemical modifications on G-quadruplex formation. The structures of tetramolecular quadruplexes and some higher order structures based on tetramolecular quadruplexes are also described.
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