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Updated: May 3, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
Neonatal morbidity occurs despite pulmonary maturity prior to 39 weeks gestation
J P Vanderhoeven1, S E Peterson1, E E Gannon1
1Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA.
Objective:
To compare outcomes among late-preterm or early-term neonates according to fetal lung maturity (FLM) status.
Study Design:
We conducted a retrospective cohort study of 234 eligible singletons delivered after FLM testing before 39 weeks gestation at our center over a 2-year time period. A primary composite neonatal outcome included death and major morbidities.
Result:
The overall rate of primary composite morbidity was 25/46 (52.2%) and 61/188 (32.4%) in the immature/transitional and mature groups, respectively. After adjustment for confounders including gestational age, the composite outcome was not significantly different; adjusted odds ratio (aOR)=1.4 (confidence interval (CI)=0.7-3.0). The rate of respiratory distress syndrome was significantly higher in the immature/transitional group; odds ratio=3.4 (CI=1.1-10.3) as expected.
Conclusion:
FLM status did not correlate with the spectrum of neonatal morbidities in late-preterm and early-term births. Neonatal complications remained common in both groups.
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