Pluripotent stem cells in regenerative medicine: challenges and recent progress
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Updated: May 3, 2026

Reprogramming Induced Pluripotent Stem Cell Lines from Frozen Buffy Coat Samples
Published on: April 10, 2026
Viviane Tabar1, Lorenz Studer2
1Center for Stem Cell Biology and Department of Neurosurgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York 10065, USA.
Abstract:
After years of incremental progress, several recent studies have succeeded in deriving disease-relevant cell types from human pluripotent stem cell (hPSC) sources. The prospect of an unlimited cell source, combined with promising preclinical data, indicates that hPSC technology may be on the verge of clinical translation. In this Review, we discuss recent progress in directed differentiation, some of the new technologies that have facilitated the success of hPSC therapies and the remaining hurdles on the road towards developing hPSC-based cell therapies.
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