Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Human Genetics01:28

Human Genetics

2.0K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
2.0K
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

1.5K
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
1.5K
Epigenetic Regulation01:46

Epigenetic Regulation

28.7K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
28.7K
Epigenetic Regulation01:37

Epigenetic Regulation

3.5K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.5K
Epigenetic Regulation01:46

Epigenetic Regulation

24.1K
24.1K
Biological Influences on Intelligence01:30

Biological Influences on Intelligence

734
Intelligence is often thought to be linked to brain size, but the relationship is more complex than that. While brain size does correlate modestly with some abilities, like verbal skills, the connection is weaker for others, such as spatial reasoning. Other factors, like brain structure, also play crucial roles. For instance, despite Einstein's smaller-than-average brain, his parietal cortex, which is involved in spatial reasoning, was 15% wider, suggesting that neural density might matter...
734

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Navigating Human Astrocyte Differentiation: Direct and Rapid One-Step Differentiation of Induced Pluripotent Stem Cells to Functional Astrocytes Supporting Neuronal Network Development.

Glia·2026
Same author

The microtubule-binding protein EML3 is required for mammalian embryonic growth and cerebral cortical development, and Eml3 null mice are a model of cobblestone brain malformation.

eLife·2026
Same author

Astrocytes contribute to olanzapine-mediated reversal of Kleefstra Syndrome-associated neurodevelopmental regression.

The Journal of clinical investigation·2026
Same author

Generation of isogenic rescue iPSC lines by targeted CTG-repeat excision for myotonic dystrophy type 1.

Stem cell research·2026
Same author

Biallelic rescue of CTG18.1 in two Fuchs endothelial corneal dystrophy-derived iPSC lines (SCTCi047-A-2, SCTCi046-A-2) following a two-step gene editing strategy.

Stem cell research·2026
Same author

Generation of iPSC lines from myotonic dystrophy type 1 patients with varying CTG repeat lengths.

Stem cell research·2026

Related Experiment Video

Updated: May 3, 2026

The Detection of 5-Hydroxymethylcytosine in Neural Stem Cells and Brains of Mice
08:03

The Detection of 5-Hydroxymethylcytosine in Neural Stem Cells and Brains of Mice

Published on: September 19, 2019

6.0K

The genetics of cognitive epigenetics.

Tjitske Kleefstra1, Annette Schenck1, Jamie M Kramer1

  • 1Radboud University Medical Center, Department of Human Genetics, Nijmegen Center for Molecular Life Sciences (NCMLS), Nijmegen, The Netherlands.

Neuropharmacology
|January 18, 2014
PubMed
Summary

Genetic research reveals epigenetic regulation is crucial for cognition. Identifying shared gene networks in cognitive disorders may lead to new therapeutic strategies for various conditions.

Keywords:
ChromatinCognitive disorderEpigeneticGeneticIntellectual disabilityMutation

More Related Videos

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain
13:11

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain

Published on: July 12, 2012

21.7K
Correlating Gene-specific DNA Methylation Changes with Expression and Transcriptional Activity of Astrocytic KCNJ10 Kir4.1
11:19

Correlating Gene-specific DNA Methylation Changes with Expression and Transcriptional Activity of Astrocytic KCNJ10 Kir4.1

Published on: September 26, 2015

7.4K

Related Experiment Videos

Last Updated: May 3, 2026

The Detection of 5-Hydroxymethylcytosine in Neural Stem Cells and Brains of Mice
08:03

The Detection of 5-Hydroxymethylcytosine in Neural Stem Cells and Brains of Mice

Published on: September 19, 2019

6.0K
Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain
13:11

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain

Published on: July 12, 2012

21.7K
Correlating Gene-specific DNA Methylation Changes with Expression and Transcriptional Activity of Astrocytic KCNJ10 Kir4.1
11:19

Correlating Gene-specific DNA Methylation Changes with Expression and Transcriptional Activity of Astrocytic KCNJ10 Kir4.1

Published on: September 26, 2015

7.4K

Area of Science:

  • Neuroscience
  • Genetics
  • Epigenetics

Background:

  • Cognitive disorders (CDs) are diverse, with genetic links increasingly understood.
  • A significant number of genes associated with CDs are involved in epigenetic regulation.
  • Epigenetic mechanisms are vital for gene transcription and human cognition.

Purpose of the Study:

  • To provide an overview of genes linked to cognitive disorders.
  • To highlight epigenetic regulatory complexes involving multiple CD genes.
  • To explore common gene networks for therapeutic development.

Main Methods:

  • Literature review of genes associated with cognitive disorders.
  • Analysis of epigenetic regulatory complexes.
  • Identification of shared gene networks and pathways.

Main Results:

  • Numerous gene mutations are associated with cognitive disorders.
  • Epigenetic gene regulation plays a critical role in cognition.
  • Mutant genes often co-operate in shared protein complexes and pathways, leading to similar neurodevelopmental phenotypes.

Conclusions:

  • Epigenetic regulation is a key process in cognitive function and disorders.
  • Shared gene networks in CDs offer potential therapeutic targets.
  • Understanding these networks may enable treatments for diverse cognitive disorders.