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Yeast As a Chassis for Developing Functional Assays to Study Human P53
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p53 signaling pathway polymorphisms associated to recurrent pregnancy loss

L R Fraga1, C G Dutra, J A Boquett

  • 1Post-Graduation Program in Genetics and Molecular Biology, Departament of Genetics, Biosciences Institute, Universidade Federal do Rio Grande do Sul (UFRGS), Caixa Postal 15031 - Agencia Campus UFRGS, Porto Alegre, RS, 91501-970, Brazil, lucas_r_fraga@hotmail.com.

Molecular Biology Reports
|January 18, 2014
PubMed
Summary

The TP53 Pro72Arg polymorphism and MDM2 SNP309 are studied for recurrent pregnancy loss (RPL). A combination of TP53 Arg/Arg and MDM2 TT genotypes increases RPL risk, suggesting a potential genetic predisposition.

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