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Updated: May 3, 2026
A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
A centralized recipient database enhances the serologic safety of RBC transfusions for patients with sickle cell
Sarah K Harm1, Mark H Yazer, Grace F Monis
1Puget Sound Blood Center, 921 Terry Ave, Seattle, WA 98104; meghand@psbc.org.
Objectives:
To evaluate the utility of a centralized transfusion service model in preventing the transfusion of incompatible units in patients with sickle cell disease (SCD).
Methods:
The serologic records of transfused patients with SCD were reviewed. The index hospital was where an alloantibody was initially detected.
Results:
In total, 150 patients with SCD were evaluated; 66 (44.0%) of 150 were alloimmunized. In 42 (63.6%) of these patients, 1 or more antibodies evanesced. The median number of hospitals visited by patients with SCD for RBC transfusion with 1 or more evanesced antibodies was three (range, one to eight); the median number of nonindex hospitals was two (range, one to seven). Of the patients with evanesced antibodies, 28.6% received transfusions at various nonindex hospitals 20 or more times after the antibody evanesced.
Conclusions:
A centralized database can help identify patients with SCD who have evanesced alloantibodies and prevent issuing incompatible RBC units.
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