Related Experiment Video
Updated: May 1, 2026

Sample Drift Correction Following 4D Confocal Time-lapse Imaging
Published on: April 13, 2014
Frequency and phase drift correction of magnetic resonance spectroscopy data by spectral registration in the time
Jamie Near1, Richard Edden2, C John Evans3
1Douglas Mental Health University Institute and Department of Psychiatry, McGill University, Montreal, Canada.
Purpose:
Frequency and phase drifts are a common problem in the acquisition of in vivo magnetic resonance spectroscopy (MRS) data. If not accounted for, frequency and phase drifts will result in artifactual broadening of spectral peaks, distortion of spectral lineshapes, and a reduction in signal-to-noise ratio (SNR). We present herein a new method for estimating and correcting frequency and phase drifts in in vivo MRS data.
Methods:
We used a simple method of fitting each spectral average to a reference scan (often the first average in the series) in the time domain through adjustment of frequency and phase terms. Due to the similarity with image registration, this method is referred to as "spectral registration." Using simulated data with known frequency and phase drifts, the performance of spectral registration was compared with two existing methods at various SNR levels.
Results:
Spectral registration performed well in comparison with the other methods tested in terms of both frequency and phase drift estimation.
Conclusions:
Spectral registration provides an effective method for frequency and phase drift correction. It does not involve the collection of navigator echoes, and does not rely on any specific resonances, such as residual water or creatine, making it highly versatile.
More Related Videos
08:54NMR Spectroscopy as a Robust Tool for the Rapid Evaluation of the Lipid Profile of Fish Oil Supplements
Published on: May 1, 2017
10:28Measuring Interactions of Globular and Filamentous Proteins by Nuclear Magnetic Resonance Spectroscopy NMR and Microscale Thermophoresis MST
Published on: November 2, 2018
Related Concept Videos
NMR Spectrometers: Overview
¹H NMR: Interpreting Distorted and Overlapping Signals
As Δν decreases and the signals move closer, the doublets appear increasingly distorted. The intensities of the inner lines increase at the cost of those of the outer lines as the signals are...
Two-Dimensional (2D) NMR: Overview
The first step is the preparation period, during which nucleus A is excited with a radiofrequency pulse....
NMR Spectrometers: Resolution and Error Correction
NMR Spectroscopy: Chemical Shift Overview
For instance, the proton...
NMR Spectrometers: Radiofrequency Pulses and Pulse Sequences