Related Experiment Video
Updated: May 3, 2026

Intracoronary Acetylcholine Provocation Testing for Assessment of Coronary Vasomotor Disorders
Published on: August 18, 2016
Coronary Artery Spasm in Multivessel ACS: What More Should We Know?
Abhishek Jaiswal1, Gregory Gustafson1, Emmanuel N Moustakakis1
1Division of Cardiology, Department of Internal Medicine, New York Hospital Queens/Weill Medical College of Cornell University, New York, New York.
Insights
Coronary spasm can mimic acute coronary syndrome (ACS), complicating diagnosis and treatment. Identifying spasm with vasodilators can prevent unnecessary stenting and improve patient outcomes.
Area of Science:
- Cardiology
- Vascular Medicine
- Interventional Cardiology
Background:
- Acute coronary syndrome (ACS) encompasses ST-segment elevation myocardial infarction (STEMI), non-STEMI, and unstable angina.
- The prevalence and impact of coronary artery spasm in ACS patients are not well-defined.
- Concomitant coronary spasm can obscure underlying atherosclerotic disease, leading to diagnostic and therapeutic challenges.
Observation:
- This case report details the management of an ACS patient with both coronary spasm and atherosclerotic disease.
- The patient presented with symptoms suggestive of ACS, requiring careful diagnostic evaluation.
Findings:
- Routine vasodilator administration in ACS cases can help identify underlying coronary spasm.
- Prompt identification of coronary spasm can prevent inappropriate stenting procedures.
Implications:
- Recognizing and treating coronary spasm in ACS is crucial for accurate diagnosis and effective management.
- Preventing inappropriate stenting in spasm cases can significantly improve clinical outcomes for ACS patients.
- This highlights the importance of considering coronary spasm in the differential diagnosis of ACS.
Abstract:
Coronary spasm may present as acute coronary syndrome (ACS), "which can be an ST segment elevation myocardial infarction (STEMI), non-STEMI, or unstable angina." However, the prevalence of coronary spasm in patients with ACS remains unknown due to scarcity of data. Concomitant coronary spasm may mask the true atherosclerosis burden in such cases, posing several management challenges. We illustrate the case of managing an ACS patient with concomitant spasm and atherosclerotic disease. We show that the routine use of vasodilator treatment in ACS cases may prevent inappropriate stenting by identifying concomitant coronary spasm, influencing the clinical outcomes associated with inappropriate stenting in the setting of coronary spasm.
Related Concept Videos
Acute Coronary Syndrome I: Introduction
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
Acute Coronary Syndrome III: Diagnostic Studies
Acute Coronary Syndrome V: Nursing Management
Acute Coronary Syndrome IV: Interprofessional Care
Coronary Artery Disease V: Interprofessional Care

