Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

395
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
395
Aging01:26

Aging

1.1K
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
1.1K
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

367
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
367
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

354
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
354
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

382
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
382
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

400
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
400

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[In process]

Bulletin de la Societe des sciences medicales du Grand-Duche de Luxembourg·2018
Same author

[The flexibility of family medicine].

Bulletin de la Societe des sciences medicales du Grand-Duche de Luxembourg·2016
Same author

[The first 7 months of activities in a psychogeriatric unit in Luxembourg].

Bulletin de la Societe des sciences medicales du Grand-Duche de Luxembourg·1993
Same author

[Possible correlations of principle parameters in alcoholics: apropos of 100 cases in Luxembourg].

Bulletin de la Societe des sciences medicales du Grand-Duche de Luxembourg·1983
Same journal

Recommendations for the neuropsychological assessment supporting the diagnosis of dementia in the Luxembourgish context (NP-DiaDem).

Bulletin de la Societe des sciences medicales du Grand-Duche de Luxembourg·2018
Same journal

[Not Available].

Bulletin de la Societe des sciences medicales du Grand-Duche de Luxembourg·2018
Same journal

Promotion of physical activity in patients with non-communicable diseases in Luxembourg: a follow-up of the Sport-Sante inventory from 2014.

Bulletin de la Societe des sciences medicales du Grand-Duche de Luxembourg·2018
Same journal

Retrospective analysis of cardiac events during cardiac rehabilitation at Centre Hospitalier de Luxembourg during 2014 and 2015.

Bulletin de la Societe des sciences medicales du Grand-Duche de Luxembourg·2018
Same journal

Case Report: Primary Spinal Lymphoma.

Bulletin de la Societe des sciences medicales du Grand-Duche de Luxembourg·2018
Same journal

[In process].

Bulletin de la Societe des sciences medicales du Grand-Duche de Luxembourg·2018
See all related articles

Related Experiment Video

Updated: May 3, 2026

Clinical Practice Protocol of Creative Music Therapy for Preterm Infants and Their Parents in the Neonatal Intensive Care Unit
11:50

Clinical Practice Protocol of Creative Music Therapy for Preterm Infants and Their Parents in the Neonatal Intensive Care Unit

Published on: January 7, 2020

28.6K

Music and elderly.

J C Leners

    Bulletin De La Societe Des Sciences Medicales Du Grand-Duche De Luxembourg
    |January 21, 2014
    PubMed
    Summary
    This summary is machine-generated.

    Music therapy offers a side-effect-free complementary treatment for various conditions, including neurological diseases and end-of-life care. This approach is increasingly recognized for its positive physiological and emotional impacts.

    More Related Videos

    Subcutaneous Neurotrophin 4 Infusion Using Osmotic Pumps or Direct Muscular Injection Enhances Aging Rat Laryngeal Muscles
    05:50

    Subcutaneous Neurotrophin 4 Infusion Using Osmotic Pumps or Direct Muscular Injection Enhances Aging Rat Laryngeal Muscles

    Published on: June 13, 2017

    8.0K
    Author Spotlight: Innovations in iTUG Test for Enhanced Risk Assessment and Cognitive Insights
    05:26

    Author Spotlight: Innovations in iTUG Test for Enhanced Risk Assessment and Cognitive Insights

    Published on: October 25, 2024

    1.9K

    Related Experiment Videos

    Last Updated: May 3, 2026

    Clinical Practice Protocol of Creative Music Therapy for Preterm Infants and Their Parents in the Neonatal Intensive Care Unit
    11:50

    Clinical Practice Protocol of Creative Music Therapy for Preterm Infants and Their Parents in the Neonatal Intensive Care Unit

    Published on: January 7, 2020

    28.6K
    Subcutaneous Neurotrophin 4 Infusion Using Osmotic Pumps or Direct Muscular Injection Enhances Aging Rat Laryngeal Muscles
    05:50

    Subcutaneous Neurotrophin 4 Infusion Using Osmotic Pumps or Direct Muscular Injection Enhances Aging Rat Laryngeal Muscles

    Published on: June 13, 2017

    8.0K
    Author Spotlight: Innovations in iTUG Test for Enhanced Risk Assessment and Cognitive Insights
    05:26

    Author Spotlight: Innovations in iTUG Test for Enhanced Risk Assessment and Cognitive Insights

    Published on: October 25, 2024

    1.9K

    Area of Science:

    • Neurology
    • Therapeutics
    • Gerontology

    Background:

    • Music therapy has evolved over 30 years as an educational, recreational, and therapeutic intervention.
    • Its efficacy as a complementary therapy with no known side-effects is increasingly supported by medical research.

    Observation:

    • Music therapy demonstrates positive outcomes across a spectrum of conditions.
    • Applications range from pulmonary disorders to chronic neurological diseases such as aphasia, dementia, and Parkinson's disease.

    Findings:

    • The review will cover evidence-based results on physiological and hormonal changes associated with music therapy.
    • Music therapy plays a significant role in emotional expression and support, particularly at the end of life.

    Implications:

    • Music therapy presents a viable, non-pharmacological approach for managing chronic conditions and improving quality of life.
    • Further research into the physiological mechanisms of music therapy can enhance its clinical application and patient care.