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[Impaired cardiac structural and functional parameters in patients with chronic heart failure and diabetic cardiac

M E Statsenko, S V Turkina, S S Shalaeva

    Terapevticheskii Arkhiv
    |January 21, 2014
    PubMed

    Insights

    Diabetic cardiac autonomic neuropathy in chronic heart failure patients is linked to increased left ventricular mass and QT dispersion. This suggests autonomic dysregulation impacts cardiac structure and function.

    Area of Science:

    • Cardiology
    • Diabetology
    • Neurology

    Background:

    • Chronic heart failure (CHF) and type 2 diabetes mellitus (DM2) are prevalent conditions.
    • Diabetic cardiac autonomic neuropathy (CAN) is a common complication affecting cardiovascular health.
    • Understanding the interplay between CHF, DM2, and CAN is crucial for patient management.

    Purpose of the Study:

    • To elucidate specific cardiac structural and functional characteristics in patients with both CHF and diabetic CAN.
    • To investigate the impact of CAN severity on cardiac parameters in patients with CHF and DM2.

    Main Methods:

    • A cohort of 90 patients (aged 45-70) with Functional Class I-III CHF post-myocardial infarction and DM2 were studied.
    • Group 1 (n=60) had signs of CAN; Group 2 (n=60) served as a control without CAN.
    • Cardiac structural and functional features were assessed, including left ventricular mass, QT dispersion, and heart rate variability.

    Main Results:

    • Patients with CHF, DM2, and CAN exhibited higher left ventricular mass indices compared to those without CAN.
    • Greater QT dispersion was observed in patients with CAN.
    • Significant reductions in heart rate variability and a prevalence of hypersympathicotonia were noted in the CAN group.

    Conclusions:

    • A significant relationship exists between cardiac autonomic dysregulation, CAN severity, and cardiac structural/functional parameters in patients with CHF and DM2.
    • Diabetic CAN contributes to adverse cardiac remodeling and electrical instability in CHF patients.
    • These findings highlight the importance of assessing and managing CAN in this patient population.
    Abstract

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