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Updated: May 3, 2026

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
Published on: September 8, 2021
[Dilated cardiomyopathy in patients with schizophrenia]
Aim:
To study the frequency of pathoanatomic and some clinical signs of dilated cardiomyopathy (DCM) in schizophrenic patients (SPs).
Subjects And Methods:
Autopsy records were studied in 838 SPs treated at a psychiatric hospital in 1952 to 2007. The records were used to select DCM cases (n = 74) and sudden deaths (n = 101) and to examine 339 electrocardiograms (ECG). The 2006-2007 information obtained in the dissecting rooms of three Tver hospitals (1413 sections) was analyzed.
Results:
DCM was absent (neuroleptics were not used) before 1956. With the application of neuroleptics, the diagnosis of DCM cases significantly increased and its rate was 14.2% among the dead SPs. DCM might be a cause of sudden death in 21.8% of SPs. The rate of pathological ECG signs noticeably increased with the longer use of neuroleptics. In the hospital-wide network, the detection rate for DCM was 0.5% of the autopsies.
Conclusion:
The use of neuroleptics, in SPs in particular, may lead to the development of DCM.
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