Related Experiment Video
Updated: May 3, 2026

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings
Published on: June 13, 2025
[Chronotherapy--present and future]
1Division of Clinical Pharmacology, Department of pharmacology, Jichi Medical University School of Medicine.
Abstract:
Chronotherapy integrates chronoeffective and chronotoxic data to enhance an effectiveness and tolerance of a drug by choosing optimal dosing-time. Chronotherapy is already performed in several diseases such as hypertension, osteoporosis, dyslipidemia and malignant diseases, and improves the prognosis of these patients. However, it is still a new concept for physicians. Efforts are needed to take chronotherapy into dosage regimen by physicians, who have a major role in providing the benefits of chronotherapy to their patients. In addition, chronotherapy studies are not requested for drug evaluations by the regulatory authorities. However, preliminary screening of new drugs for their chronotherapeutic potential is a way of enhancing the research and development in pharmaceutical industries.
Related Concept Videos
Chronopharmacokinetics: Time-Dependent Pharmacokinetics
Time-dependent pharmacokinetics refers to non-cyclical changes in drug rate processes over a period of time. It can lead to nonlinear pharmacokinetics, where the relationship between drug concentration and time is not proportional. Non-cyclical...
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
Biological Clocks and Seasonal Responses
Circadian Rhythms and Gene Regulation
Circadian Rhythms and Gene Regulation
Framing Effects

