Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

498
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
498
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

3.4K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
3.4K
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

2.1K
2.1K
Regulation of Stroke Volume01:27

Regulation of Stroke Volume

7.3K
The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
7.3K
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

30
A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
30
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

54
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
54

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quantitative Assessment of Caregiver Quality of Life Across Dementia Severity Using a Utility-Weighted Scale Based on a Conjoint Analysis.

Internal medicine (Tokyo, Japan)·2026
Same author

Association Between a 1-Year Group-Based Telerehabilitation Program and the Quality of Life of People With Parkinson's Disease: An Observational Study.

Archives of physical medicine and rehabilitation·2026
Same author

Dual Antiplatelet Therapy With Cilostazol for Secondary Prevention in Lacunar Stroke: Subanalysis of the CSPS.com Trial.

Stroke·2023
Same author

[The questionnaire survey regarding the impact of COVID-19 pandemic on Parkinson's disease patients].

Rinsho shinkeigaku = Clinical neurology·2021
Same author

Dual Antiplatelet Therapy Using Cilostazol in Patients With Stroke and Intracranial Arterial Stenosis.

Journal of the American Heart Association·2021
Same author

Dual Antiplatelet Therapy Using Cilostazol With Aspirin or Clopidogrel: Subanalysis of the CSPS.com Trial.

Stroke·2021

Related Experiment Video

Updated: May 3, 2026

Gathering Self-Initiated Rat Behavioral Data to Characterize Post-Stroke Deficits
05:08

Gathering Self-Initiated Rat Behavioral Data to Characterize Post-Stroke Deficits

Published on: March 15, 2024

2.1K

[Circadian rhythm and stroke].

Yasuo Terayama1

  • 1Division of Neurology and Gerontology, Department of Internal Medicine, School of Medicine, Iwate Medical University.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|January 21, 2014
PubMed
Summary

Circadian rhythm disruptions can lead to stroke by affecting blood pressure and coagulation. Understanding these biological rhythms is crucial for stroke prevention and treatment.

Area of Science:

  • Neuroscience
  • Cardiovascular Science
  • Sleep Medicine

Context:

  • Stroke incidence is linked to circadian rhythm alterations.
  • Pathologically reduced circadian variation is a known stroke risk factor.
  • Both ischemic and hemorrhagic strokes share common pathophysiological patterns related to circadian factors.

Purpose:

  • To explore the intricate relationship between circadian rhythms and stroke.
  • To identify key circadian rhythm components influencing stroke incidence.
  • To highlight the role of blood pressure and coagulation rhythms in cerebrovascular events.

Summary:

  • Circadian rhythms, influenced by both internal biological clocks and external factors, play a significant role in stroke.
  • Key factors include vascular tone, coagulation, blood pressure, physical activity, and stress.

More Related Videos

Recording and Analysis of Circadian Rhythms in Running-wheel Activity in Rodents
05:46

Recording and Analysis of Circadian Rhythms in Running-wheel Activity in Rodents

Published on: January 24, 2013

21.2K
Simultaneous Photothrombosis and Fiber Photometry to Induce and Monitor Ischemic Stroke in Behaving Mice
07:49

Simultaneous Photothrombosis and Fiber Photometry to Induce and Monitor Ischemic Stroke in Behaving Mice

Published on: November 14, 2025

688

Related Experiment Videos

Last Updated: May 3, 2026

Gathering Self-Initiated Rat Behavioral Data to Characterize Post-Stroke Deficits
05:08

Gathering Self-Initiated Rat Behavioral Data to Characterize Post-Stroke Deficits

Published on: March 15, 2024

2.1K
Recording and Analysis of Circadian Rhythms in Running-wheel Activity in Rodents
05:46

Recording and Analysis of Circadian Rhythms in Running-wheel Activity in Rodents

Published on: January 24, 2013

21.2K
Simultaneous Photothrombosis and Fiber Photometry to Induce and Monitor Ischemic Stroke in Behaving Mice
07:49

Simultaneous Photothrombosis and Fiber Photometry to Induce and Monitor Ischemic Stroke in Behaving Mice

Published on: November 14, 2025

688
  • The temporal patterns of blood pressure and coagulation are particularly critical for cerebral vessel health.

    • Impact:

    • Provides insights into the pathophysiology of stroke.
    • Suggests potential chronotherapeutic strategies for stroke prevention.
    • Emphasizes the importance of considering circadian health in neurological and cardiovascular care.